The Star has reported that road closures are in place on the East Lancs in Haydock following the collision.
Police are appealing for information after the crash, which saw a truck hit a lamppost.
Paramedics took the man, who is in his 50s, to hospital where he is receiving treatment.
Police remain at the scene with closures in place.
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A Merseyside Police spokeswoman said: “We are appealing for information following a road traffic collision yesterday evening, Wednesday, November 1, on the East Lancashire Road in Haydock.
“At around 11.40pm, we received a report that a man, in his 50s, driving a truck was in collision with a lamppost. No other vehicles were involved.
“Paramedics took the man to hospital where he is receiving treatment.
“Police are still at the scene to manage the traffic.”
She added: “Road closures are in place on Liverpool Road, East Lancashire Road and Millfield Lane East (Manchester bound) while emergency services attend the incident.
“We ask that drivers avoid the area and find an alternative route. We thank you for your patience as we deal with this incident.
“Anyone who witnessed the collision or captured anything on CCTV or dashcam DM @MerPolCC or Crimestoppers on 0800 555 111, quoting reference 1134 of November 1.”
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